Dendritic cell regulation of TH1-TH2 development

Nat Immunol. 2000 Sep;1(3):199-205. doi: 10.1038/79734.


Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription factors. Less is understood about the molecular basis of TH1-TH2 development exerted by other parameters, such as how the antigen presenting cell can influence this process. Recent work suggests that dendritic cell subsets contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. In some cases known pathways may be used, as in the dendritic cell subset 1 exerting TH1 polarization by interleukin 12 (IL-12) production and STAT4 activation. In others, the effects are still in need of explanation.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / immunology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Interleukin-12 / biosynthesis
  • Interleukin-12 / immunology
  • STAT4 Transcription Factor
  • Th1 Cells / cytology
  • Th1 Cells / immunology*
  • Th2 Cells / cytology
  • Th2 Cells / immunology*
  • Trans-Activators / immunology


  • DNA-Binding Proteins
  • STAT4 Transcription Factor
  • STAT4 protein, human
  • Trans-Activators
  • Interleukin-12