Evaluation of Two Slide Agglutination Tests and a Novel Immunochromatographic Assay for Rapid Diagnosis of Infectious Mononucleosis

Clin Diagn Lab Immunol. 2000 Sep;7(5):840-1. doi: 10.1128/cdli.7.5.840-841.2000.

Abstract

The results of three tests used for the rapid diagnosis of infectious mononucleosis (IM) were compared with those of Epstein-Barr virus-specific serology. The sensitivities ranged from 15 to 33% in children under 13 years of age and from 59 to 81% in patients over 13 years. The specificities ranged from 86 to 100% in both age groups. These tests have a poor sensitivity for the diagnosis of IM, particularly in children.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Agglutination Tests / methods*
  • Animals
  • Antibodies, Heterophile / blood
  • Antibodies, Viral / blood
  • Cattle
  • Child
  • Child, Preschool
  • Chromatography, Affinity / methods*
  • Epstein-Barr Virus Nuclear Antigens / immunology
  • Female
  • Guinea Pigs
  • Herpesvirus 4, Human / immunology
  • Horses
  • Humans
  • Immunoglobulin M / blood
  • Infant
  • Infectious Mononucleosis / blood
  • Infectious Mononucleosis / diagnosis*
  • Infectious Mononucleosis / immunology
  • Male
  • Middle Aged
  • Reagent Kits, Diagnostic*
  • Time Factors

Substances

  • Antibodies, Heterophile
  • Antibodies, Viral
  • Epstein-Barr Virus Nuclear Antigens
  • Immunoglobulin M
  • Reagent Kits, Diagnostic