Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women

Cancer Detect Prev. 2000;24(3):199-206.


We explored the relationship between insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk. Also, we examined whether obesity, sex hormone-binding globulin (SHBG), and estradiol influenced IGF-1 concentrations. A pilot study of 60 postmenopausal African-American women (30 cases and 30 controls) was used. Plasma concentrations of IGF-1 were higher among the cases, as compared to the controls. A negative trend was seen for plasma concentrations of IGF-1 and TNM (tumor-node-metastasis) stage and IGF-1 and body mass index. IGF-1 was found to be associated negatively with SHBG. After adjustment, plasma concentrations of IGF-1 remained significantly and positively associated with breast cancer risk (odds ratio, 1.183; 95% confidence interval, 1.167-1.201). No significant associations for breast cancer risk were observed for estradiol, SHBG, and body mass index. Further research with a larger sample is needed to clarify the relationships between obesity and IGF-1 concentrations to breast cancer risk in this population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group
  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Breast Neoplasms / blood
  • Breast Neoplasms / metabolism*
  • Case-Control Studies
  • Estradiol / biosynthesis
  • Female
  • Humans
  • Insulin-Like Growth Factor I / biosynthesis*
  • Middle Aged
  • Obesity
  • Pilot Projects
  • Postmenopause
  • Risk Factors
  • Sex Hormone-Binding Globulin / biosynthesis


  • Sex Hormone-Binding Globulin
  • Estradiol
  • Insulin-Like Growth Factor I