Advances in mass spectrometry for proteome analysis

Curr Opin Biotechnol. 2000 Aug;11(4):384-90. doi: 10.1016/s0958-1669(00)00114-2.


The most demanding problems in proteomics continue to challenge modern mass spectrometry. Recent developments in instrument design have led to lower limits of detection, while new ion activation techniques and improved understanding of gas-phase ion chemistry have enhanced the capabilities of tandem mass spectrometry for peptide and protein structure elucidation. Future developments must address the., understanding of protein-protein interactions and the characterisation of the dynamic proteome.

Publication types

  • Review

MeSH terms

  • Databases, Factual
  • Mass Spectrometry / instrumentation
  • Mass Spectrometry / methods*
  • Peptides / analysis
  • Peptides / chemistry
  • Proteins / analysis*
  • Proteins / chemistry


  • Peptides
  • Proteins