Stress or drug priming induces reinstatement of extinguished conditioned place preference

Neuroreport. 2000 Aug 21;11(12):2781-4. doi: 10.1097/00001756-200008210-00034.


To construct a model for the relapse of drug use, we investigated the reinstatement of morphine-induced conditioned place preference (CPP) in rats. After the morphine CPP paradigm was established, rats were left extinguishing for 9 days, then exposed to 15 min of random foot shock or s.c. drug priming with different doses of morphine or amphetamine, respectively. Foot shock or a higher dose (0.25 mg/kg) of both drugs could reinstate the CPP induced by 4 mg/kg of morphine after a 9-day extinction, while a lower dose (0.125 mg/kg) of both drugs had no effect. It is concluded that the CPP extinction-reinstatement paradigm might be used as a model to investigate the mechanism of relapse in addicts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphetamine / pharmacology
  • Animals
  • Central Nervous System Stimulants / pharmacology
  • Conditioning, Psychological / drug effects*
  • Conditioning, Psychological / physiology*
  • Electroshock
  • Environment*
  • Male
  • Morphine / pharmacology*
  • Morphine Dependence / psychology*
  • Narcotics / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Recurrence
  • Space Perception / physiology*
  • Stress, Physiological / psychology*


  • Central Nervous System Stimulants
  • Narcotics
  • Morphine
  • Amphetamine