Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery

J Med Chem. 2000 Sep 7;43(18):3351-71. doi: 10.1021/jm000060f.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemical synthesis
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects*
  • Caspase 1 / chemistry
  • Caspase 1 / genetics
  • Caspase 1 / metabolism
  • Caspases / chemistry
  • Caspases / deficiency
  • Caspases / genetics
  • Caspases / metabolism*
  • Cysteine Proteinase Inhibitors / chemical synthesis
  • Cysteine Proteinase Inhibitors / chemistry*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Cytokines / metabolism
  • Drug Design
  • Humans
  • Signal Transduction
  • Substrate Specificity

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Cysteine Proteinase Inhibitors
  • Cytokines
  • Caspases
  • Caspase 1