Abstract
Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure-activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.
MeSH terms
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Benzophenones / chemistry
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Benzophenones / pharmacology*
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Butadienes / chemistry
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Butadienes / pharmacology*
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Chromatography, Gel
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Chromatography, High Pressure Liquid
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Fruit / chemistry*
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Gas Chromatography-Mass Spectrometry
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Hemiterpenes*
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Humans
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KB Cells / drug effects
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Magnetic Resonance Spectroscopy
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Malaysia
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Microtubules / drug effects*
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Optical Rotation
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Pentanes*
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Plants, Medicinal / chemistry*
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Rosales / chemistry*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Structure-Activity Relationship
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Tubulin / analysis
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Tubulin / biosynthesis
Substances
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Benzophenones
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Butadienes
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Hemiterpenes
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Pentanes
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Tubulin
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isoprene
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xanthochymol
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guttiferone E