Hyaluronan: a multifunctional, megaDalton, stealth molecule

Curr Opin Cell Biol. 2000 Oct;12(5):581-6. doi: 10.1016/s0955-0674(00)00135-6.


Hyaluronan has been implicated in biological processes such as cell adhesion, migration and proliferation. Traditionally, it was thought to be associated with the extracellular matrix, but, hyaluronan may also have unimagined roles inside the cell. Investigation of hyaluronan synthesis and degradation, the identification of new receptors and binding proteins, and the elucidation of hyaluronan-dependent signaling pathways are providing novel insights into the true biological functions of this fascinating molecule.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Extracellular Matrix / metabolism
  • Glucuronosyltransferase / metabolism
  • Glycosyltransferases*
  • Humans
  • Hyaluronan Receptors / metabolism
  • Hyaluronan Synthases
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / metabolism
  • Hyaluronic Acid / physiology*
  • Membrane Proteins*
  • Molecular Weight
  • Signal Transduction
  • Transferases*
  • Xenopus Proteins*


  • Hyaluronan Receptors
  • Membrane Proteins
  • Xenopus Proteins
  • Hyaluronic Acid
  • Transferases
  • Glycosyltransferases
  • Glucuronosyltransferase
  • HAS1 protein, Xenopus
  • Hyaluronan Synthases