Mechanism of homophilic cadherin adhesion

Curr Opin Cell Biol. 2000 Oct;12(5):587-92. doi: 10.1016/s0955-0674(00)00136-8.


Direct measurements of the distance-dependent forces between membrane-bound cadherins were used to test current models of homophilic cadherin interactions. The results reveal a complex binding mechanism in which the proteins adhere in multiple alignments that involve more than the amino-terminal domains.

Publication types

  • Review

MeSH terms

  • Animals
  • Cadherins / chemistry
  • Cadherins / physiology*
  • Cadherins / ultrastructure
  • Cell Adhesion / physiology*
  • Dimerization
  • Microscopy, Electron
  • Models, Molecular
  • Protein Conformation


  • Cadherins