IgCAMs: bidirectional signals underlying neurite growth

Curr Opin Cell Biol. 2000 Oct;12(5):598-605. doi: 10.1016/s0955-0674(00)00138-1.


Understanding how immunoglobulin superfamily cell adhesion molecules (IgCAMs) regulate nervous system development has lagged behind studies on integrins and cadherins. The recent characterization of IgCAM structures combined with cell biological studies on protein-protein interactions and membrane targeting/trafficking demonstrate that IgCAMs interact in exceedingly complex ways to regulate axonal growth and pathfinding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / physiology*
  • Gene Expression Regulation
  • Humans
  • MAP Kinase Signaling System / physiology
  • Neurites / physiology*
  • Signal Transduction*


  • Cell Adhesion Molecules