Remarkable roles of proteolysis on and beyond the cell surface

Curr Opin Cell Biol. 2000 Oct;12(5):606-12. doi: 10.1016/s0955-0674(00)00139-3.


Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Extracellular Matrix / metabolism*
  • Growth Substances / metabolism
  • Humans
  • Matrix Metalloproteinases / metabolism*
  • Matrix Metalloproteinases / physiology
  • Membrane Proteins / metabolism*
  • Receptors, Cell Surface / metabolism*


  • Cytokines
  • Growth Substances
  • Membrane Proteins
  • Receptors, Cell Surface
  • Matrix Metalloproteinases