The functions of thrombospondin-1 and-2

Curr Opin Cell Biol. 2000 Oct;12(5):634-40. doi: 10.1016/s0955-0674(00)00143-5.


Considerable progress has been made towards understanding the function of thrombospondin-1 and-2. The description of the phenotype of mice with thrombospondin-1 and-2 knocked-out supports in vitro biochemical and cell-biological data and has opened new avenues of research. Recently, our understanding of the roles of thrombospondins in the activation of TGFbeta, inhibition of angiogenesis and the initiation of signal transduction has advanced.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Angiogenesis Inhibitors / physiology
  • Animals
  • Humans
  • Molecular Sequence Data
  • Signal Transduction
  • Thrombospondin 1 / physiology*
  • Thrombospondins / physiology*
  • Transforming Growth Factor beta / metabolism


  • Angiogenesis Inhibitors
  • Thrombospondin 1
  • Thrombospondins
  • Transforming Growth Factor beta
  • thrombospondin 2