High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients

Blood. 2000 Sep 15;96(6):2069-73.


Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 visits, whereas patients were in chemotherapy-induced clinical remission at 50 visits. Symptoms were associated with a high level of serum C reactive protein, high HHV8 viral load in peripheral blood mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral load suggest that both cytokines may be involved in the pathogenesis of this virus-associated lymphoproliferative disorder.

MeSH terms

  • Adult
  • Aged
  • Biomarkers
  • C-Reactive Protein / metabolism*
  • Castleman Disease / blood*
  • Castleman Disease / etiology
  • Castleman Disease / virology*
  • HIV Infections / complications*
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Interleukin-10 / blood*
  • Interleukin-6 / blood*
  • Middle Aged
  • Predictive Value of Tests
  • Viral Load


  • Biomarkers
  • Interleukin-6
  • Interleukin-10
  • C-Reactive Protein