Susceptibility of fluconazole-resistant clinical isolates of Candida spp. to echinocandin LY303366, itraconazole and amphotericin B

J Antimicrob Chemother. 2000 Sep;46(3):475-7. doi: 10.1093/jac/46.3.475.


The in vitro activity of LY303366 was compared with those of itraconazole and amphotericin B against 156 fluconazole-resistant (MIC > or = 16 mg/L) clinical isolates of Candida spp. An adaptation of the NCCLS reference method was employed for determination of MICs. LY303366 was more potent than either itraconazole or amphotericin B against Candida albicans, Candida glabrata, Candida krusei and Candida tropicalis, even against isolates with itraconazole MICs > or = 1 mg/L. LY303366 was less potent in vitro against Candida parapsilosis and Candida guilliermondii isolates. LY303366 has promising antifungal activity and warrants further investigation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Anidulafungin
  • Antifungal Agents / pharmacology*
  • Candida / drug effects*
  • Candidiasis / microbiology
  • Drug Resistance, Microbial
  • Echinocandins
  • Fluconazole / pharmacology*
  • Humans
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests / methods
  • Microbial Sensitivity Tests / standards
  • Peptides, Cyclic / pharmacology*


  • Antifungal Agents
  • Echinocandins
  • Peptides, Cyclic
  • Itraconazole
  • Amphotericin B
  • Fluconazole
  • Anidulafungin