Toll signaling: the enigma variations

Curr Opin Genet Dev. 2000 Oct;10(5):497-502. doi: 10.1016/s0959-437x(00)00118-0.

Abstract

Experiments reported in the past year have revealed considerable diversity in Toll-mediated pathways for signal transduction in development and innate immunity. Rather than function as a well conserved signaling cassette, Toll receptors and associated factors have apparently evolved as a diverse set of configurations to defend against microbial infection in species ranging from plants to humans.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila / genetics
  • Drosophila / physiology
  • Drosophila Proteins*
  • Humans
  • Insect Proteins / genetics
  • Insect Proteins / physiology*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Receptors, Immunologic*
  • Signal Transduction*
  • Toll-Like Receptor 5
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Tl protein, Drosophila
  • Toll-Like Receptor 5
  • Toll-Like Receptors
  • tehao protein, Drosophila