Genetic control of cell size

Curr Opin Genet Dev. 2000 Oct;10(5):529-35. doi: 10.1016/s0959-437x(00)00123-4.


Over the past 25 years, the genetic control of cell size has mainly been addressed in yeast, a single-celled organism. Recent insights from Drosophila have shed light on the signalling pathways responsible for adjusting and maintaining cell size in metazoans. Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Size / genetics*
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / growth & development*
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoric Monoester Hydrolases / metabolism
  • Proto-Oncogene Proteins c-myc / physiology
  • Receptor, Insulin / physiology
  • Signal Transduction
  • Tumor Suppressor Proteins*


  • Proto-Oncogene Proteins c-myc
  • Tumor Suppressor Proteins
  • Phosphatidylinositol 3-Kinases
  • Receptor, Insulin
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase