The role of chromosomal RNAs in marking the X for dosage compensation

Curr Opin Genet Dev. 2000 Oct;10(5):555-61. doi: 10.1016/s0959-437x(00)00127-1.

Abstract

Both flies and mammals remodel the architecture of the X chromosome to achieve dosage compensation. A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding these unusual RNAs are themselves located on the X, and are key sites that target the X for dosage compensation.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / genetics
  • Chromatin / metabolism
  • DNA-Binding Proteins
  • Dosage Compensation, Genetic*
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Humans
  • Nuclear Proteins / metabolism
  • RNA / genetics
  • RNA / physiology*
  • RNA, Long Noncoding
  • RNA, Untranslated*
  • RNA-Binding Proteins / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription Factors / physiology
  • X Chromosome / genetics*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Nuclear Proteins
  • Pabp2 protein, Drosophila
  • RNA, Long Noncoding
  • RNA, Untranslated
  • RNA-Binding Proteins
  • Transcription Factors
  • XIST non-coding RNA
  • msl-1 protein, Drosophila
  • msl-2 protein, Drosophila
  • RNA