Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies

Neurology. 2000 Sep 12;55(5):713-5. doi: 10.1212/wnl.55.5.713.


The outcome of 34 women with anti-Yo-associated paraneoplastic cerebellar degeneration was reviewed. Three patients had not developed cancer after more than 4 years of follow-up. The only independent predictor for survival was the type of associated tumor (risk ratio, 1.79; 95% CI, 1.02 to 3.12). Median survival was 100 months for patients with breast cancer and 22 for those with gynecologic cancer. Although paraneoplastic cerebellar degeneration leads to the diagnosis of cancer in 63% of the patients, cancer progression was the cause of death in 52%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Neoplasms / physiopathology
  • Female
  • Genital Neoplasms, Female / physiopathology
  • Humans
  • Middle Aged
  • Paraneoplastic Cerebellar Degeneration / mortality
  • Paraneoplastic Cerebellar Degeneration / physiopathology*
  • Prognosis
  • Survival Analysis
  • Time Factors