Scanning laser entoptic perimetry for the screening of macular and peripheral retinal disease

Arch Ophthalmol. 2000 Sep;118(9):1205-10. doi: 10.1001/archopht.118.9.1205.


Objective: To determine the effectiveness of scanning laser entoptic perimetry as a noninvasive platform for screening for retinal damage in visually asymptomatic patients within the central 120 degrees (diameter) of vision.

Design: A masked study comparing entoptic perimetry with fundus photographs.

Setting: The Shiley Eye Center and the AIDS Ocular Research Unit at the University of California, San Diego.

Patients: Fifty-eight patients recruited during ophthalmologic visits for treatment or follow-up of ocular disease.

Measurements: For each testing session, we compared the presence of a disturbance in the entoptic stimulus with the presence of retinal disease within the central 120 degrees of vision, centered on the fovea.

Results: Scanning laser entoptic perimetry has a sensitivity and specificity of more than 90%, a positive predictive value of 100%, and a negative predictive value of 89% for screening retinal lesions within the central 120 degrees diameter of vision.

Conclusion: Scanning laser entoptic perimetry may be an effective and inexpensive screening test for diagnosing retinal disease in hospitals and community clinics. Arch Ophthalmol. 2000;118:1205-1210

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • False Positive Reactions
  • Female
  • Fundus Oculi
  • Humans
  • Lasers*
  • Macula Lutea / pathology*
  • Male
  • Photography / methods
  • Predictive Value of Tests
  • Retinal Diseases / diagnosis*
  • Scotoma / diagnosis*
  • Sensitivity and Specificity
  • Visual Acuity
  • Visual Field Tests / methods*
  • Visual Fields*