Pathophysiology of obesity hypertension

Curr Hypertens Rep. 2000 Apr;2(2):139-47. doi: 10.1007/s11906-000-0073-4.


Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with weight gain. Activation of the renin-angiotensin and sympathetic nervous systems and physical compression of the kidneys appear to contribute to obesity-induced increases in sodium reabsorption and hypertension.

Publication types

  • Review

MeSH terms

  • Fatty Acids / metabolism
  • Hemodynamics
  • Humans
  • Hypertension / etiology*
  • Hypertension / physiopathology
  • Kidney / physiopathology*
  • Leptin / physiology
  • Natriuresis / physiology
  • Obesity / complications*
  • Obesity / metabolism
  • Obesity / physiopathology*
  • Renin-Angiotensin System / physiology
  • Sodium / metabolism
  • Sympathetic Nervous System / physiopathology


  • Fatty Acids
  • Leptin
  • Sodium