What can knockout mice contribute to an understanding of hypertension?

Curr Hypertens Rep. 2000 Apr;2(2):192-7. doi: 10.1007/s11906-000-0081-4.

Abstract

The generation of knockout mice using homologous recombination in embryonic stem cells is a powerful tool for physiologic investigations. This experimental approach has provided unique insights into the study of hypertension. Studies using knockout mice have shed new light on blood pressure regulatory mechanisms, molecular mechanisms of end-organ injury, and genetic mechanisms for hypertension. With the development of more accessible approaches for carrying out sophisticated manipulation of the mouse genome, there will be continuing utility of this technique for future studies of hypertension.

Publication types

  • Review

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Angiotensinogen / genetics
  • Angiotensinogen / physiology
  • Animals
  • Disease Models, Animal*
  • Gene Expression
  • Humans
  • Hypertension / genetics*
  • Hypertension / physiopathology*
  • Mice
  • Mice, Knockout*
  • Phenotype
  • Receptors, Angiotensin / genetics
  • Receptors, Angiotensin / physiology*
  • Renin-Angiotensin System / physiology
  • Stem Cells

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Receptors, Angiotensin
  • Angiotensinogen