Misfolding of membrane proteins in health and disease: the lady or the tiger?

Curr Opin Struct Biol. 2000 Aug;10(4):438-42. doi: 10.1016/s0959-440x(00)00112-3.


Protein misfolding is increasingly recognized as a factor in many diseases, including cystic fibrosis, Parkinson's, Alzheimer's and atherosclerosis. Many proteins involved in misfolding-based pathologies are membrane-associated, such that the bilayer may play roles in normal and aberrant folding. It can be argued that the in vivo partitioning of eukaryotic membrane proteins between folding and misfolding pathways is under kinetic control. Moreover, the balance between these pathways can be surprisingly delicate.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / metabolism
  • Animals
  • Arteriosclerosis / etiology
  • Arteriosclerosis / metabolism
  • Cystic Fibrosis / etiology
  • Cystic Fibrosis / metabolism
  • Humans
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Parkinson Disease / etiology
  • Parkinson Disease / metabolism
  • Protein Folding*
  • Signal Transduction
  • Structure-Activity Relationship


  • Membrane Proteins