beta-Barrel Membrane Proteins

Curr Opin Struct Biol. 2000 Aug;10(4):443-7. doi: 10.1016/s0959-440x(00)00120-2.


beta-Barrel proteins are found in the outer membranes of bacteria, mitochondria and chloroplasts. The presently known sizes range from small eight-stranded to large twenty-two-stranded beta barrels existing as monomers and oligomers. Their functions are as diverse as active ion transport, passive nutrient intake, membrane anchors, membrane-bound enzymes and defense against attack proteins. Of further interest are the folding process, the crystallization, the observed limited structural diversity and the manifold channel engineering options of these beta-barrel proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Membrane Proteins*
  • Protein Engineering*
  • Protein Folding*


  • Membrane Proteins