STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene

Nucleic Acids Res. 2000 Sep 15;28(18):3442-4. doi: 10.1093/nar/28.18.3442.


The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genes, Bacterial / physiology
  • Information Storage and Retrieval
  • Internet*
  • Mycoplasma / enzymology
  • Mycoplasma / genetics
  • Operon
  • Software*
  • Substrate Specificity
  • tRNA Methyltransferases / metabolism


  • tRNA Methyltransferases