The murine Bis1 seizure gene and the Kcnab2 gene encoding the beta2-subunit of the K+ channel are different

Neurogenetics. 2000 Mar;2(4):231-4. doi: 10.1007/pl00022974.


We tested the hypothesis that Bis1, a gene involved in seizure regulation in mice which has been localized to the distal part of chromosome 4, was the same as the gene Kcnab2, encoding the beta2-subunit for voltage-dependent K+ channels. Two facts suggested this hypothesis: Kcnab2 is located in the 3.1-cM confidence interval containing Bis1 and many studies have shown an involvement of K+ channels in the genesis of seizures. DNA sequence analysis of the coding sequence for Kcnab2 from JE/Le mice revealed no structural alterations which might affect Kcnab2 function. However, several nucleotide changes were observed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Confidence Intervals
  • Mice
  • Mice, Neurologic Mutants
  • Potassium Channels / chemistry
  • Potassium Channels / genetics*
  • Protein Subunits
  • Seizures / genetics*


  • Potassium Channels
  • Protein Subunits