Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia

Planta Med. 2000 Aug;66(6):569-71. doi: 10.1055/s-2000-8605.


Bakuchiol, a meroterpene isolated from Psoralea corylifolia, prevented mitochondrial lipid peroxidation. Inhibition of oxygen consumption originating in lipid peroxidation was time-dependent. Bakuchiol protected mitochondrial respiratory enzyme activities against both NADPH-dependent and dihydroxyfumarate-induced peroxidation injury. Bakuchiol was shown to be effective to protect mitochondrial functions against oxidative stress.

Publication types

  • Letter

MeSH terms

  • Animals
  • Fabaceae / chemistry*
  • Lipid Peroxidation / drug effects*
  • Mitochondria, Liver / drug effects*
  • Mitochondria, Liver / metabolism
  • Phenols / chemistry
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Plants, Medicinal*
  • Rats


  • Phenols
  • bakuchiol