Use of antioxidants to treat pain in chronic pancreatitis

Rev Esp Enferm Dig. 2000 Jun;92(6):375-85.
[Article in En, Spanish]


Objective: The purpose of this report is to analyze the results of a 1-year clinical study of antioxidant therapy in the treatment of pain and recurrent inflammatory episodes in patients with chronic and acute recurrent pancreatitis, using a prospective, descriptive, pre-post, open design. The intensity of pain at the beginning and end of treatment was assessed with a visual analogue scale, and these results along with the number of hospital admissions for pancreatic disease were analyzed.

Methods: We studied patients with acute recurrent or chronic pancreatitis who had suffered from pain or acute inflammatory episodes the year before the beginning of treatment with a complex containing L-methionine, beta-carotene, vitamin C, vitamin E and organic selenium.

Results: Of 10 patients with chronic pancreatitis who completed treatment, the intensity of pain was reduced considerably in 9 (61.5 +/- 21.5 mm vs. 19.6 +/- 26.1 mm, p = 0.03), and pain was completely absent in 3 of these patients. Twelve patients who completed treatment had fewer hospital admissions during the year with antioxidant treatment than they had had during the previous year (1.5 +/- 1.62 vs. 0.25 +/- 0.45 admissions, p = 0.03).

Conclusions: Antioxidant treatment had a positive effect in patients who suffered from pancreatic inflammatory pain, and its effectiveness should be tested before more aggressive and costlier treatments are considered.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antioxidants / therapeutic use*
  • Chronic Disease
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Pain / drug therapy*
  • Pain / etiology
  • Pancreatitis / complications*
  • Prospective Studies


  • Antioxidants