Immunocytochemical localization of lung-type prostaglandin F synthase in the rat spinal cord

Brain Res. 2000 Sep 22;877(2):391-5. doi: 10.1016/s0006-8993(00)02709-8.

Abstract

Prostaglandin F synthase, producing prostaglandin F(2 alpha) and 9 alpha,11 beta-prostaglandin F(2), has at least two isozymes, lung-type and liver-type ones. The present study including double immunolabelling with microtubule-associated protein 2 indicated that the lung-type isozyme was present in neuronal dendrites and somata of gray matter (relatively intense in lamina I and II in dorsal horn, and IX in ventral horn) and vascular endothelial cells in the rat spinal cord at all segmental levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dendrites / enzymology
  • Dendrites / ultrastructure
  • Endothelium, Vascular / enzymology
  • Endothelium, Vascular / ultrastructure
  • Hydroxyprostaglandin Dehydrogenases / metabolism*
  • Isoenzymes / metabolism*
  • Lung / enzymology*
  • Neurons / enzymology*
  • Neurons / ultrastructure
  • Rats
  • Spinal Cord / enzymology*
  • Spinal Cord / ultrastructure

Substances

  • Isoenzymes
  • Hydroxyprostaglandin Dehydrogenases
  • prostaglandin-F synthase