[Insulin precursors--a historical synopsis. First diabetes treatment trials using pancreas extracts]

Arzneimittelforschung. 1975 Mar;25(3):439-42.
[Article in German]


The highly interesting and successful attempts to treat diabetes with pancreas extracts deserve a historical review. Some of these experiments were performed long before the isolation and use of insulin by the Canadians Banting, Best, Macleod and Collip in 1921--22. Successful isolation of insulin, known as acomatol and pancreatin, was first carried out before the Canadian research-workers published their results. Particular credit goes above all to Paulesco, Reuter and Zuelzer.

Publication types

  • English Abstract
  • Historical Article

MeSH terms

  • Canada
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / history
  • Germany
  • History, 19th Century
  • History, 20th Century
  • Insulin / history*
  • Pancreatic Extracts / therapeutic use*
  • Romania


  • Insulin
  • Pancreatic Extracts