Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Bioorg Med Chem Lett. 2000 Sep 4;10(17):1959-62. doi: 10.1016/s0960-894x(00)00380-2.

Abstract

Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Lipopolysaccharides / metabolism*
  • Mice
  • Nitric Oxide / biosynthesis
  • Polyamines / metabolism*
  • Spermine / metabolism*
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Lipopolysaccharides
  • Polyamines
  • Tumor Necrosis Factor-alpha
  • Spermine
  • Nitric Oxide