Kasumigamide, an antialgal peptide from the cyanobacterium Microcystis aeruginosa

J Org Chem. 2000 Sep 22;65(19):5898-900. doi: 10.1021/jo991918f.

Abstract

Kasumigamide (1), a novel antialgal tetrapeptide containing an N-terminal alpha-hydroxy acid, was isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-87). Its structure was elucidated by two-dimensional (1)H-(1)H and (1)H-(13)C NMR correlation experiments and confirmed by mass spectral and amino acid analyses. The absolute stereochemistry of 1 was determined by chemical studies. This peptide showed an antialgal activity against the green alga Chlamydomonas neglecta (NIES-439).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / analysis
  • Chlorophyta / drug effects*
  • Chromatography, High Pressure Liquid
  • Magnetic Resonance Spectroscopy
  • Microcystis / chemistry*
  • Oligopeptides / chemistry*
  • Oligopeptides / isolation & purification
  • Oligopeptides / toxicity
  • Pesticides / chemical synthesis*
  • Pesticides / pharmacology
  • Spectrometry, Mass, Fast Atom Bombardment

Substances

  • Amino Acids
  • Oligopeptides
  • Pesticides
  • kasumigamide