Effect of D-002 on gastric mucus composition in ethanol-induced ulcer

Pharmacol Res. 2000 Oct;42(4):329-32. doi: 10.1006/phrs.2000.0693.

Abstract

This study was designed to determine the effect of D-002, a natural product isolated and purified from beeswax (Apis mellifera), on gastric mucus composition on ethanol-induced ulcer in rats. The morphology of the lesions was analysed histologically, and morphometric analysis of gastric-gland content in total glycoprotein and sulphated macromolecules were done. Oral pretreatment with D-002 at 5 and 25 mgkg(-1)1 before oral administration of ethanol at 60%, produced a significant increase in the amount of gastric mucus and total protein. The histomorphometric evaluation of the gastric damage at the same doses showed a significant increase in neutral glycoproteins and sulfated macromolecules. It is concluded that enhancement of the quantity and quality of the mucus could partly explain the gastroprotective effect of D-002.

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology
  • Ethanol
  • Fatty Alcohols / pharmacology*
  • Fatty Alcohols / therapeutic use
  • Male
  • Mucus / chemistry
  • Mucus / drug effects*
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / metabolism
  • Waxes / chemistry

Substances

  • Anti-Ulcer Agents
  • D 002
  • Fatty Alcohols
  • Waxes
  • beeswax
  • Ethanol