Soluble intercellular adhesion molecule-1 (sICAM-1) and interferon-gamma in bronchoalveolar lavage fluid from children with airway diseases

Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1016-22. doi: 10.1164/ajrccm.162.3.9902101.


We have previously described that in bronchoalveolar lavage fluid (BALF), eosinophils characterize asthma and neutrophils are more prominent in infantile wheeze. In this study, we hypothesized that intercellular adhesion molecule 1 (ICAM-1) and interferon-gamma (IFN-gamma) would have a role in promoting migration of both cell types into the airway. To investigate this, we measured soluble (s) ICAM-1 in 68 BALFs from infants and young children with various respiratory problems. Children with asthma were characterized by significantly raised sICAM compared with those with chronic cough without wheeze (p = 0.05) or control subjects with no lower airway pathology (p = 0.045). The levels correlated with disease severity (evaluated with a symptom score) and with lymphocyte numbers. IFN-gamma levels were also raised in children with asthma compared with those with chronic cough (p = 0.05), but there was no correlation with disease activity. Infantile wheeze was characterized by a linear correlation between sICAM-1 and IFN-gamma (r = 0.55; p = 0.002). sICAM-1 levels in infantile wheeze correlated with the severity of the disease and lymphocyte numbers. IFN-gamma levels were elevated in the wheezers treated with inhaled steroids compared with untreated infants (p = 0.03). Although sICAM-1 levels were increased in those with severe cough, no characteristic inflammatory profile was found in the group with chronic cough. Our study suggests that ICAM-1 and IFN-gamma play a role in the activity of the inflammatory process in asthma in childhood and possibly in some infant wheezers, in whom IFN-gamma may be one of the factors increasing the expression of ICAM-1. The role of IFN-gamma, a T helper-1 cytokine, in children with asthma remains to be fully understood.

MeSH terms

  • Adolescent
  • Asthma / diagnosis*
  • Asthma / immunology
  • Bronchoalveolar Lavage Fluid / immunology*
  • Child
  • Child, Preschool
  • Eosinophils / immunology
  • Female
  • Humans
  • Infant
  • Intercellular Adhesion Molecule-1 / analysis*
  • Interferon-gamma / analysis*
  • Leukocyte Count
  • Lung Diseases, Fungal / diagnosis*
  • Lung Diseases, Fungal / immunology
  • Male
  • Neutrophils / immunology
  • Pneumonia, Bacterial / diagnosis*
  • Pneumonia, Bacterial / immunology
  • Respiratory Hypersensitivity / diagnosis*
  • Respiratory Hypersensitivity / immunology
  • Sensitivity and Specificity


  • Intercellular Adhesion Molecule-1
  • Interferon-gamma