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. 2000 Sep 1;118(1-2):1-14.
doi: 10.1016/s0047-6374(00)00152-4.

Transgenic Methods for Increasing Drosophila Life Span


Transgenic Methods for Increasing Drosophila Life Span

J Tower. Mech Ageing Dev. .


At least five different transgenic approaches have been applied to the study of Drosophila aging. There are two single component systems: transgenes with native (normal) promoters and transgenes with heterologous promoters; as well as three binary systems: 'GAL4/UAS', 'FLP-out' and 'tet-on'. These approaches vary in ability to meet several technical challenges, and the relative advantages and disadvantages of each are discussed. Using these techniques, over-expression of the hsp70, Cu/ZnSOD and MnSOD genes has each been demonstrated to increase Drosophila life span.

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