Periodontal disease and coronary heart disease risk

JAMA. 2000 Sep 20;284(11):1406-10. doi: 10.1001/jama.284.11.1406.


Context: Research has suggested a relationship between periodontal disease and coronary heart disease (CHD), but data on the association between these 2 common conditions are inconclusive due to the possibility of confounding.

Objective: To evaluate the risk of CHD in persons with periodontitis, gingivitis, or no periodontal disease.

Design: Prospective cohort study.

Setting: The First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study, conducted in 1982-1984, 1986, 1987, and 1992.

Participants: A total of 8032 dentate adults aged 25 to 74 years with no reported history of cardiovascular disease, including 1859 individuals with periodontitis, 2421 with gingivitis, and 3752 with healthy periodontal tissues.

Main outcome measure: First occurrence of death from CHD or hospitalization due to CHD, or revascularization procedures, obtained from death certificates and medical records, by baseline periodontal status.

Results: During follow-up, 1265 individuals had at least 1 CHD event, including CHD fatality (n = 468) or at least 1 hospitalization with a diagnosis of CHD (n = 1022), including coronary revascularization procedures (n = 155). After adjustment for known cardiovascular risk factors, gingivitis was not associated with CHD (hazard ratio, 1.05; 95% confidence interval, 0.88-1.26), while periodontitis was associated with a nonsignificant increased risk for CHD event (hazard ratio, 1. 14; 95% confidence interval, 0.96-1.36).

Conclusion: This study did not find convincing evidence of a causal association between periodontal disease and CHD risk. JAMA. 2000;284:1406-1410.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Coronary Disease / epidemiology
  • Coronary Disease / etiology*
  • Female
  • Follow-Up Studies
  • Gingivitis / complications
  • Health Surveys
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Periodontal Diseases / complications*
  • Periodontitis / complications
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • United States