Development of celiac disease-associated antibodies in offspring of parents with type I diabetes

Diabetologia. 2000 Aug;43(8):1005-11. doi: 10.1007/s001250051483.


Aims/hypothesis: The aim of this study was to determine the frequency and temporal development of antibodies related to celiac disease in offspring of parents with Type I (insulin-dependent) diabetes mellitus.

Methods: Sera from 913 offspring of parents with Type I diabetes prospectively followed from birth to the age of 8 years were tested for IgG-transglutaminase antibodies (IgG-tTGCAs), endomysial IgA antibodies (EMA) and gliadin antibodies.

Results: We found tTGCAs in 32 (3.5%) of the 913 relatives. Prevalence was related to age and reached 6.5% at age 8 years. Endomysial IgA antibodies were detected in 44% of the relatives with tTGCAs and 0.6% of tTGCA negative relatives and were also most prevalent (5 %) in those aged 8 years. Both tTGCAs and EMAs were more frequent in relatives with the HLA DRB1*03 DQA1*0501 DQB1*02 haplotype (7.1% and 7.2%, respectively; p < 0.005). Antigliadin antibodies were common in both tTGCA positive (42%) and negative (23%) relatives, did not show a relation with age and were less prevalent in relatives with HLA DR3 (p < 0.05). There was no association between the presence of antibodies associated with celiac disease and islet autoantibodies in these relatives. Of the relatives 15 (1.6%) had tTGCAs plus EMAs. In two of these, anti-gliadin antibodies were detected before the detection of tTGCAs and EMAs at the age of 9 months whereas none of the remainder had any antibodies associated with celiac disease before age 2 years. In three there were no detectable antigliadin antibodies in any of the samples tested. Celiac disease without clinical symptoms was diagnosed in 9 of 12 by intestinal biopsy. CONCLUSION/INTERPRETATION. A statistically significant proportion of relatives of patients with Type I diabetes have celiac disease-associated autoimmunity and the silent form of celiac disease early in life. These relatives should, therefore, be considered for celiac antibody screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / blood*
  • Celiac Disease / blood
  • Celiac Disease / genetics
  • Celiac Disease / immunology*
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / genetics*
  • Gliadin / immunology*
  • HLA-D Antigens / blood
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Infant, Newborn
  • Longitudinal Studies
  • Nuclear Family
  • Transglutaminases / immunology


  • Autoantibodies
  • HLA-D Antigens
  • Immunoglobulin A
  • Immunoglobulin G
  • Gliadin
  • Transglutaminases