Mixed connective tissue disease

Curr Opin Rheumatol. 2000 Sep;12(5):386-90. doi: 10.1097/00002281-200009000-00006.

Abstract

A defining feature of mixed connective tissue disease (MCTD) is the presence of antibodies against the U1-ribonucleoprotein (RNP) complex, but other autoantibodies in MCTD have recently been described. Research has also further elucidated the immune responses directed against U1-RNP in humans and in murine models of disease. Hypotheses implicating modified self-antigens and/or infectious agents in the pathogenesis of MCTD have been advanced. Links between the immunologic and clinical phenomena in MCTD are emerging. Longitudinal study of patients with MCTD highlights the impact of pulmonary hypertension on disease outcome.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoantibodies
  • Humans
  • Hypertension, Pulmonary / etiology
  • Mixed Connective Tissue Disease / chemically induced
  • Mixed Connective Tissue Disease / complications
  • Mixed Connective Tissue Disease / immunology*
  • Mixed Connective Tissue Disease / microbiology
  • Ribonucleoprotein, U1 Small Nuclear / immunology
  • T-Lymphocytes / immunology

Substances

  • Autoantibodies
  • Ribonucleoprotein, U1 Small Nuclear
  • SNRNP70 protein, human