Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis

J Rheumatol. 2000 Sep;27(9):2246-50.


Objective: To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels.

Methods: Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls.

Results: Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin. sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1beta.

Conclusion: Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA. suggests that TNF activated endothelial cells are the source of sE-selectin and sICAM-1 in this disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Arthritis, Juvenile / blood*
  • Arthritis, Juvenile / immunology
  • Arthritis, Juvenile / physiopathology
  • Child
  • Child, Preschool
  • E-Selectin / blood*
  • Humans
  • Intercellular Adhesion Molecule-1 / blood*
  • Interleukin-1 / blood
  • Interleukin-6 / blood
  • P-Selectin / blood*
  • Tumor Necrosis Factor-alpha / metabolism


  • E-Selectin
  • Interleukin-1
  • Interleukin-6
  • P-Selectin
  • Tumor Necrosis Factor-alpha
  • Intercellular Adhesion Molecule-1