Progeria infantum (Hutchinson-Gilford syndrome) associated with scleroderma-like lesions and acro-osteolysis: a case report and brief review of the literature

Pediatr Dermatol. Jul-Aug 2000;17(4):282-5. doi: 10.1046/j.1525-1470.2000.01775.x.


Progeria infantum (Hutchinson-Gilford syndrome) is a very rare syndrome of premature aging characterized by growth retardation and specific, progressive, premature senescent changes of the skin and other tissues. We report a 1.5-year-old girl with loss of scalp hair, eyebrows, and lashes, prominent scalp veins, micrognathia, abnormal ears, loss of subcutaneous tissue, and scleroderma-like areas over the trunk. Radiographic studies revealed coxa valga and acro-osteolysis of the terminal phalanges. The clinical and radiologic features corresponded well with progeria infantum.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Alopecia / pathology
  • Female
  • Humans
  • Infant
  • Osteolysis, Essential / pathology*
  • Progeria / pathology*
  • Scleroderma, Localized / pathology*