Bioavailability of praziquantel increases with concomitant administration of food

Antimicrob Agents Chemother. 2000 Oct;44(10):2903-4. doi: 10.1128/aac.44.10.2903-2904.2000.

Abstract

In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antiplatyhelmintic Agents / administration & dosage
  • Antiplatyhelmintic Agents / pharmacokinetics*
  • Area Under Curve
  • Biological Availability
  • Chromatography, High Pressure Liquid
  • Diet
  • Dietary Carbohydrates / pharmacology
  • Dietary Fats / pharmacology
  • Food-Drug Interactions*
  • Half-Life
  • Humans
  • Middle Aged
  • Praziquantel / administration & dosage
  • Praziquantel / pharmacokinetics*
  • Tablets

Substances

  • Antiplatyhelmintic Agents
  • Dietary Carbohydrates
  • Dietary Fats
  • Tablets
  • Praziquantel