Sensitivity of NGF-responsive dorsal root ganglion neurons to semaphorin D is maintained in both neonatal and adult mice

Exp Neurol. 2000 Oct;165(2):394-8. doi: 10.1006/exnr.2000.7477.


Using a coculture assay of DRG neurons and aggregates of cells transfected with individual semaphorins, we have investigated the ability of semaphorins A, D, and E to inhibit axonal growth from DRG neurons. We show that axons of these neurons that grow in response to NGF remain responsive to semaphorin D in neonatal and in adult mice, although sensitivity may decline in the latter. Consistent with these findings, expression of the semaphorin receptor, neuropilin-1, is maintained in the DRGs of adult mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Axons / drug effects
  • Axons / physiology
  • Cells, Cultured
  • Ganglia, Spinal / drug effects*
  • Ganglia, Spinal / physiology
  • Glycoproteins / pharmacology*
  • Mice
  • Nerve Growth Factors / pharmacology*
  • Neurons / drug effects*
  • Neurons / physiology
  • Semaphorin-3A


  • Glycoproteins
  • Nerve Growth Factors
  • Semaphorin-3A