Hepatocellular carcinoma arising in non-cirrhotic liver in genetic haemochromatosis

Scand J Gastroenterol. 2000 Aug;35(8):889-93. doi: 10.1080/003655200750023282.


The occurrence of primary hepatocellular carcinoma (HCC) in patients with genetic haemochromatosis (GH) with cirrhosis is well known. In the past it has been suggested that patients with GH without cirrhosis have the same risk of HCC and life expectancy as the general population. However, recently there have been cases of HCC arising in non-cirrhotic livers, and we report another such case. A review of the literature has been included.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Autopsy
  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / pathology*
  • Disease Progression
  • Fatal Outcome
  • Hemochromatosis / complications*
  • Hemochromatosis / genetics*
  • Humans
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / pathology
  • Liver Neoplasms / etiology
  • Liver Neoplasms / pathology*
  • Male