A family of heptahelical receptors with adhesion-like domains: a marriage between two super families

J Recept Signal Transduct Res. 2000 May-Aug;20(2-3):119-31. doi: 10.3109/10799890009150640.


Some G protein-coupled receptors (GPCRs) are regulators of cell adhesion via inside-out effector signaling pathways. Such is the case with leukocyte chemokine receptors which stimulate intracellular second messenger pathways resulting in upregulation of integrin adhesion to ligands present in the extracellular matrix or on opposing cells resulting in chemotaxis and extravasation during immune surveillance. Remarkably, a family of GPCRs has recently been discovered that may themselves be triggered by cell-cell or cell-matrix interactions. Along with a canonical heptahelical membrane-spanning region, these intriguing proteins contain putative cell adhesion-like modules. The evidence to date suggests that they are involved in lymphocyte activation, macrophage biology, synaptic exocytosis and planar polarization during organogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD
  • Cell Adhesion*
  • Exocytosis
  • GTP-Binding Proteins / physiology*
  • Humans
  • Membrane Glycoproteins / physiology
  • Molecular Sequence Data
  • Receptors, Cell Surface / chemistry*
  • Receptors, G-Protein-Coupled / agonists
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / physiology*
  • Signal Transduction


  • ADGRE5 protein, human
  • Antigens, CD
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins