Synapse formation: if it looks like a duck and quacks like a duck ..

Curr Biol. 2000 Sep 7;10(17):R620-3. doi: 10.1016/s0960-9822(00)00663-1.

Abstract

Neuroligin and neurexin form an intercellular adhesion complex sufficient to trigger formation of functional presynaptic elements in vitro. This single molecular interaction appears to initiate clustering of synaptic vesicles, assembly of vesicle-release machinery and morphological changes at the presynaptic membrane.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology
  • Protein Binding
  • Synapses / physiology*

Substances

  • Nerve Tissue Proteins