Tumor suppressors: linking cell polarity and growth control

Curr Biol. 2000 Sep 7;10(17):R624-6. doi: 10.1016/s0960-9822(00)00658-8.


The Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear to act in a common pathway. Mutations in any of these genes lead to loss of apical-basal cell polarity and overproliferation of epithelia, revealing a close connection between cytoarchitecture and growth control.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / genetics
  • Cell Polarity / genetics*
  • Drosophila / embryology
  • Drosophila / genetics
  • Genes, Tumor Suppressor*
  • Humans