Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis

Acta Trop. 2000 Oct 23;77(1):147-52. doi: 10.1016/s0001-706x(00)00128-5.

Abstract

The several steps in the pathway for the biosynthesis of fibrillar collagen are reviewed to illustrate potential sites for the chemotherapeutic control of fibrosis. Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking of extracellular collagen molecules converting these to insoluble fibers, and upon the properties and inhibition of prolyl hydroxylase, the intracellular enzyme which hyroxylates proline residues within collagen.

Publication types

  • Review

MeSH terms

  • Aminopropionitrile / pharmacology
  • Animals
  • Benzylamines / pharmacology
  • Cells, Cultured
  • Collagen / biosynthesis*
  • Collagen / genetics
  • Enzyme Inhibitors / pharmacology*
  • Esters / pharmacology
  • Ethylamines / pharmacology
  • Fibrosis / prevention & control
  • Humans
  • Lactones / pharmacology
  • Procollagen-Proline Dioxygenase / antagonists & inhibitors*
  • Procollagen-Proline Dioxygenase / metabolism
  • Protein-Lysine 6-Oxidase / antagonists & inhibitors*
  • Protein-Lysine 6-Oxidase / metabolism

Substances

  • Benzylamines
  • Enzyme Inhibitors
  • Esters
  • Ethylamines
  • Lactones
  • 2-bromoethylamine
  • Aminopropionitrile
  • Collagen
  • Procollagen-Proline Dioxygenase
  • Protein-Lysine 6-Oxidase