The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer

Eur J Obstet Gynecol Reprod Biol. 2000 Oct;92(2):251-7. doi: 10.1016/s0301-2115(99)00295-x.


Objective: The aim of this study was to analyse the vascular endothelial growth factor (VEGF) expression in a series of cervical carcinomas and to compare the results with the microvessel density (MVD) and clinicopathological features.

Study design: The immunoreactivity for VEGF was studied in 130 invasive cervical carcinomas and in 22 patients with a carcinoma in situ of the cervix. The results were compared with the MVD.

Results: Staining for VEGF of less then 50% per slide occurred in 80% of the invasive carcinomas and in 82% of the in situ carcinomas. The median MVD was 261 vv/mm(2) (range: 11-1000) in the invasive group and 146 vv/mm(2) (range: 25-536) in the in situ group. Unlike the microvessel density there was no association between VEGF expression and survival. The MVD was higher in VEGF poorer (<50%) tumours (P=0.055). Beside tumour histology (P=0.012) there were no other significant relationships between the remaining histopathological findings and VEGF expression.

Conclusion: Tissue VEGF expression has no prognostic value in contrast with the MVD in patients with invasive cervical cancer.

MeSH terms

  • Adenocarcinoma / blood supply
  • Adenocarcinoma / chemistry
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Carcinoma, Adenosquamous / blood supply
  • Carcinoma, Adenosquamous / chemistry
  • Carcinoma, Adenosquamous / pathology
  • Carcinoma, Squamous Cell / blood supply
  • Carcinoma, Squamous Cell / chemistry
  • Carcinoma, Squamous Cell / pathology
  • Endothelial Growth Factors / analysis*
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphokines / analysis*
  • Microcirculation / pathology*
  • Middle Aged
  • Prognosis
  • Uterine Cervical Neoplasms / blood supply*
  • Uterine Cervical Neoplasms / chemistry*
  • Uterine Cervical Neoplasms / pathology
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors


  • Endothelial Growth Factors
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors