Diabetes insipidus in neurobrucellosis

Clin Neurol Neurosurg. 2000 Sep;102(3):163-5. doi: 10.1016/s0303-8467(00)00089-5.


Brucellosis is an infection due to Brucella species and is characterized by acute febrile illness, chilly sensations, sweats, weakness, generalized malaise, body aches and headache. The involvement of the nervous system is rare. A few cases have been reported with symptoms and sign of optic neuritis, meningoencephalitis, meningomyelitis and cranial nerve palsy. We report a case with culture proven neurobrucellosis who presented with diabetes insipidus along with systemic signs. Neuroimaging revealed multiple lesions in brain parenchyma, including the suprasellar region. Both diabetes and suprasellar lesions improved markedly with specific antibiotic therapy.

Publication types

  • Case Reports

MeSH terms

  • Brain / microbiology
  • Brain / pathology
  • Brucella / isolation & purification*
  • Brucellosis / complications*
  • Brucellosis / etiology
  • Brucellosis / microbiology
  • Central Nervous System Bacterial Infections / etiology
  • Central Nervous System Bacterial Infections / microbiology*
  • Diabetes Insipidus / etiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Pituitary Diseases / etiology
  • Pituitary Diseases / microbiology*