Abstract
Unrelated translocases extrude proteins or antimicrobial agents across both membranes of the cell envelope in Gram-negative bacteria. The TolC protein links the translocases to the external environment. The recently determined crystal structure of TolC shows how this universal tunnel operates.
MeSH terms
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Bacterial Outer Membrane Proteins / chemistry
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Proteins / metabolism*
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Biological Transport
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Carrier Proteins / metabolism*
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Escherichia coli / metabolism*
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Escherichia coli Proteins*
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Hemolysin Proteins
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Lipoproteins / metabolism
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Membrane Proteins / metabolism
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Membrane Transport Proteins*
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Models, Molecular
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Multidrug Resistance-Associated Proteins
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Protein Conformation
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Protein Transport
Substances
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AcrA protein, E coli
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AcrB protein, E coli
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Carrier Proteins
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EmrA protein, E coli
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Escherichia coli Proteins
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Hemolysin Proteins
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HlyD protein, E coli
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Hlyb protein, Bacteria
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Lipoproteins
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Membrane Proteins
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Membrane Transport Proteins
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Multidrug Resistance-Associated Proteins
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tolC protein, E coli
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emrA protein, Bacteria
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VceB protein, Vibrio cholerae