A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

Neurosci Res. 2000 Sep;38(1):3-17. doi: 10.1016/s0168-0102(00)00139-5.

Abstract

Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The alpha-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus-dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Signaling / physiology
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Hippocampus / cytology
  • Hippocampus / enzymology*
  • Long-Term Potentiation / physiology*
  • Memory / physiology*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Neurological*
  • Neural Inhibition / physiology
  • Neurons / metabolism
  • Phosphorylation
  • Signal Transduction / physiology
  • Synapses / metabolism

Substances

  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases